DEY, DEBENDRANATH (Total 181 Patents Found)

A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro- alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extr...
Compounds are provided that lower blood glucose concentrations, lower serum triglyceride concentrations, lower systolic blood pressure, and increase glucose uptake by adipose tissue, but do not affect the expression of PPAR-η by adipose tissue....
Un compuesto de la fórmula (I)**Fórmula** y formas tautoméricas, estereoisómeros, polimorfos, hidratos, sales farmacéuticamente aceptables y solvatosfarmacéuticamente aceptables de los mismos, donde ---- representa un enlace opcional; V representa CH o N; Y esO; W representa O o NR8; R8 se selecciona de hidrógen...
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a va...
The present invention provides a new medical use for the compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof, as MAO-A inhibitors. Also included is a method for pro...
The present invention relates to novel hydroxamic acid containing amino acid derivatives that are useful for treatment of inflammation, inflammatory and immunological diseases; lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels; and for treatment or prophylaxis of metabolic dis...
The present invention relates to novel tyrosine derivatives of formula (I), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel tyrosine derivatives of the general formula (I)....
Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis....
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabe...
Novel diphenylethylene and styrenes are provided which are administered orally to decrease blood glucose levels in rats. The glucose tolerance in insulin resistant rats is also shown, as well as lowering of triglyceride levels in serum insulin resistant, hyperinsulinemic and hypertriglycedemic rats. The compounds are o...
The present invention relates to novel heterocyclic derivatives of the general formula (I), their pharmaceutically acceptable salts and compositions, their analogs, their tautomeric forms, and their stereoisomers. The present invention more particularly provides novel compounds of the general formula (I)....
L’invention concerne une méthode et une composition pour atténuer un ou plusieurs symptômes associés à un état pathologique induit pour une ou plusieurs cyclooxygénases, une cytokine pro-inflammatoire, et une enzyme pro-inflammatoire. Ladite méthode consiste à administrer une quantité efficace d’une compo...
L'invention concerne des isoquinoléines, des isochromanones et des isothiochromanones substituées inhibant des cytokines pro-inflammatoires telles que le facteur de nécrose tumorale alpha (TNF-alpha), l'interleukine 6 (IL-6), l'enzyme cyclooxygénase 2 (COX-2) et/ou l'interleukine 10 (IL-10). L'i...
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol...
A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extra...
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. In contrast to previously reported thiazolidin...
The present invention relates to novel pyridine derivatives of the formula (I), their stereoisomers, and their pharmaceutically acceptable salts, and compositions. The present invention more particularly provides novel pyridine derivatives of the general formula (I)....
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol...
L'invention concerne de nouveaux dérivés de tyrosine représentés par la formule (I), leurs sels pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables comprenant ces dérivés. L'invention concerne, plus particulièrement, de nouveaux dérivés de tyrosine représentés par la for...
L'invention concerne de nouveaux dérivés hétérocycliques de formule (I) et leurs sels pharmaceutiquement acceptables, leurs dérivés, leurs analogues, leurs formes tautomères, leurs stéréosimères, leurs polymorphes, leurs hydrates, leurs solvates, leurs sels pharmaceutiquement acceptables, leurs compositio...
Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a va...
La présente invention concerne une nouvelle utilisation médicale des composés de formule (I), leurs dérivés, leurs analogues, leurs formes tautomères, leurs stéréoisomères, leurs polymorphes, leurs hydrates, leurs solvates, leurs sels pharmaceutiquement acceptables et leurs compositions, leurs métabolites et ...
A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extr...
本发明提供包含噻唑烷二酮或恶唑烷二酮部分的新型二苯基乙烯化合物及其衍生物,其有效降低II型糖尿病动物模型中的血糖水平,血清胰岛素,甘油三酯和游离脂肪酸水平。所公开的化合物用于各种治疗,包括炎症、炎性和免疫性疾病、胰岛...
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabe...
A composition of matter comprising a synergistic formulation of plant extracts for hepatic and adrenal disorders is provided. In an implementation, an example extraction method for concentrating pharmacologically active fractions of plants provides a synergistically active compound containing approximately 5% - 25% ext...
The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The presen...
Novel hydroxamic acid containing amino acid derivatives are provided that are useful for treatment of inflammation, inflammatory and immunological diseases; lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels; and for treatment or prophylaxis of metabolic disorders....
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol...
The present invention relates to novel pyridine derivatives of the formula (I), their stereoisomers, and their pharmaceutically acceptable salts, and compositions. The present invention more particularly provides novel pyridine derivatives of the general formula (I)....
L'invention concerne de nouveaux dérivés de tyrosine représentés par la formule (I), leurs sels pharmaceutiquement acceptables et des compositions pharmaceutiquement acceptables comprenant ces dérivés. L'invention concerne, plus particulièrement, de nouveaux dérivés de tyrosine représentés par la for...
The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containi...
L'invention concerne de nouveaux dérivés d'aminoacides, utiles pour gérer des troubles tels que l'obésité et des maladies immunologiques. Ces dérivés servent également à diminuer les niveaux de glycémie lors de troubles d'hyperglycémie et à traiter des troubles associés tels que la prise de...
Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis....
Un compuesto seleccionado de: 3-(3,5-dimetoxi-fenil)-2-{4-[4-(2,4-dioxo-tiazolidin-5-ilmetil)-fenoxi]-fenil}-acrilamida, 3-(3,5-dimetoxi-fenil)-2-{4-[4-(2,4-dioxo-tiazolidin-5-ilmetil)-fenoxi]-fenil}-N,N-dimetil-acrilamida, 3-(3,5-dimetoxi-fenil)-2-{4-[4-(2,4-dioxo-tiazolidin-5-ilmetil)-fenoxi]-fenil}-N-metoxi-N-metil-...
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabe...
L'invention concerne un procédé permettant d'obtenir une ou plusieurs fractions à partir d'une matière végétale de Withania somnifera (WS). Ce procédé consiste: à soumettre ladite matière à une extraction hydro-alcoolique en présence d'un solvant insoluble dans l'eau afin d'obtenir a...
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body weight gain, elevated free fatty acid, cholesterol...
On décrit des composés qui réduisent les concentrations de glucose dans le sang, réduisent les concentrations sériques de triglycérides, réduisent la tension artérielle systolique et augmentent le recaptage du glucose par le tissu adipeux, mais qui n'affectent pas l'expression de PPAR-η par le tissu ad...