Compounds for treatment of inflammation, diabetes and related disorders

Composes servant au traitement d'une inflammation, des diabetes et des troubles associes

Abstract

Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
La présente invention concerne des acyle urée, thiourée, carbamate, thiocarbamate et autres nouveaux composés associés, permettant d'inhiber la réponse inflammatoire induite par la cytokine dans des cellules de culture, d'améliorer la destruction osseuse dans un modèle animal de l'arthrite, et de réduire les niveaux de glycémie dans des modèles animaux de diabètes sucrés de Type II. L'invention concerne des composés pouvant être utilisés dans plusieurs traitements, parmi lesquels le traitements des diabètes sucrés, de l'insulinorésistance, de l'inflammation, des maladies inflammatoires, des maladies immunologiques et du cancer.

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Cited By (8)

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    EP-1625207-A2February 15, 2006Theracos, Inc.Compounds for treatment of inflammation, diabetes and related disorders
    EP-1625207-A4November 12, 2008Theracos IncComposes servant au traitement de l'inflammation, du diabete et de troubles connexes
    US-8007790-B2August 30, 2011Stowers Institute For Medical ResearchMethods for treating polycystic kidney disease (PKD) or other cyst forming diseases
    WO-2004019986-A1March 11, 2004Schering AktiengesellschaftMethodes permettant de traiter le syndrome de detresse respiratoire aigue
    WO-2009045397-A1April 09, 2009Stowers Institute For Medical ResearchMethods for treating polycystic kidney desease (pkd) or other cyst forming diseases
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    WO-2012060594-A3June 28, 2012숙명여자대학교산학협력단, 전북대학교산학협력단Composition anti-inflammatoire contenant un composé thiourée et un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif