aryl (Total 21995 Patents Found)

Aryl (21995 Patents Found)
The present invention relates to a method of treating disorders by administering to a patient in need of such treatment a therapeutically effective amount of a compound of formula (I): wherein R 1 -R 8 are as described herein, R 4 being aryl or heteroaryl....
This invention relates to novel {overscore (ω)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular disorders (CVS) such as lipid lowering effects....
Die vorliegende Anmeldung betrifft neue, substituierte 4-Aryl-l,4-dihydro-l,6-naphthyridin-3- carboxamide, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbes...
The invention relates to 4-nitro-substituted N-(tetrazol-5-yl)-, N-(triazol-5-yl)-, and N-(1,3,4-oxadiazol-2-yl)aryl carboxylic acid amides of the general formula (I) as herbicides. In the formula (I), X, Y, and W represent groups such as hydrogen, organic groups such as alkyl, and other groups such as halogen. A repre...
A process for making a cycloalkyl phosphine comprising hydrogenating an aryl phosphine in the presence of an effective amount of an aryloxide of a metal selected from the group consisting of niobium and tantalum is disclosed. Cycloalkyl phosphine products of this process, useful as ligands in a complex of a transition ...
6-Arylpyrrolo[1,2-a]imidazole derivatives, processes for their manufacture, pharmaceutical compositions containing them and a method of using them to lower blood pressure in warm-blooded animals. Representative of the compounds disclosed is 6-(2,6-dichlorophenyl)-2,3,6,7-tetrahydro-5H-pyrrolo[1,2-a]imidazole....
The present invenion relates to rubber compositions containing a hydroxy-aryl substituted maleamic acid. The rubbers modified with the hydroxy-aryl substituted maleamic acid exhibit improved rubber/filler interaction. The hydroxy-aryl substituted maleamic acid may also be used as a replacement for resorcinol in rubber ...
Novel α-aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides are described herein. The compounds are useful as anti-arrhythmic agents. The compounds are prepared by reacting an appropriate disubstituted acetonitrile with an appropriate haloalkyl amine and subsequently hydrolyzing the resulting nitrile with concentr...
The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments. Compounds of the Formula I in which the radicals have the sta...
A process for preparing aryl ketones of the formula: FROM A COMPOUND OF THE FORMULA: THROUGH A COMPOUND OF THE FORMULA: A COMPOUND OF THE FORMULA: AND A COMPOUND OF THE FORMULA: THE SAID ARYL KETONES BEING (I) being useful as central nervous system depressants and the intermediary compounds (II), (III), and (...
Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R 1 is C 1 -C 30 alkyl, C 1 -C 18 alkyl substituted by halogen, --COOR 2 , --CN, --NR 3 R 4 or by --CONR 3 R 4 , C 2 -C 18 alkyl which is interrupted by --NR 5 --, --O-- or --S--, C 3 -C 18 alkenyl, C 5 -C 12 cycloalkyl, phenyl-C 1...
Antifungal compositions comprising an inert diluent or carrier and an alpha-aryl-N-lower alkyl nitrone are described. The compositions are advantageous in that they have activity over a wide spectrum of phytopathogenic micro-organisms while, at the same time, they are not phytotoxic to selected crop and ornamental plan...
There are disclosed compounds of the formula (I) ##STR1## wherein R 1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R 2 is unsubstituted or substi...
A composition of matter for a recording medium in atomic force data storage devices. The composition includes one or more poly(aryl ether ketone) copolymers, each of the one or more poly(aryl ether ketone) copolymers including (a) a first monomer including an aryl ether ketone and (b) a second monomer including an aryl...
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain oxy phenyl aryl compounds (referred to herein as OPA compounds), as described herein, which, inter alia, inhibit Checkpoint Kinase 2 (CHK2) kinase function. The present invention also pertains to pharmaceuti...
The present invention relates to substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious dis...
Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fungi and insects by the use of a fungitoxic or insecticidal amount o...
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this inventi...
Polyphosphazene polymers are prepared which contain units represented by the formulas: ##STR1## wherein X is ##STR2## in which R and R 1 are selected from the group consisting of alkyl groups containing from 1 to 12 carbon atoms, cycloalkyl groups containing from 3 to 12 carbon atoms and aryl groups; wherein X&#...
The invention relates to a method for producing sulfonated aryl phosphines by reacting aryl phosphines with oleum. After reacting the aryl phosphines with oleum, the sulfonation mixture is firstly diluted with water and an inert gas stream is then fed through the diluted sulfonation mixture until SO 2 is no longer rel...
The present invention relates to the use of 1-{4-[4-aryl(or heteroaryl)-1-piperazinyl]butyl}-1H-azole derivatives and of their physiologically acceptable salts for the manufacture of medicaments intended for the treatment of disorders associated with gastric secretion....
The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorders and complications thereof, such as, diabetes and obesity....
The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery...
The present invention relates to novel triazolo[4,3-a]pyridine derivatives of Formula (I) wherein all radicals are as defined in the claims. The compounds according to the invention are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”), which are useful for the treatment or ...
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1....
The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient....
L'invention porte: sur l'utilisation d'amides d'acides -2-aryl-propioniques (R) et (S) en tant qu'agents antiseptiques; sur une préparation pharmaceutique de composés de formule (I), aux propriétés antiseptiques pour le traitement d'infections gastrointestinales, muco-épidermiques et épide...